产品货号：
Z12442
中文名称：
CaMKIV/CAMK4抗体
英文名称：
Anti-CaMKIV/CAMK4 Antibody
产品规格：
100μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-CaMKIV/CAMK4 Antibody |
| 指标别名 | CaM kinase GR;CaMK GR;CAMK4;CaMKIV |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | ELISA,IHC,WB |
| 基因名称 | CAMK4 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | This antiserum was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an internal region near amino acids 300-325 of Human CaM Kinase IV protein. |
| 计算分子量 | 52kDa |
| 成分 | 0.02M Potassium Phosphate,0.15M Sodium Chloride,pH7.2,0.01% (w/v) Sodium Azide |
| 纯化方式 | This antiserum is directed against human CaM Kinase IV protein.The product was delipidated,defibrinated followed by buffering and clarification.A BLAST analysis was used to suggest reactivity with this protein from human,mouse,and rat based on 100% homology for the immunogen sequence.Cross-reactivity with CaM Kinase IV homologues from other sources has not been determined. |
| 浓度 | 70mg/mL by Refractometry |
| 产品形态 | Lyophilized |
| 保存条件 | Store vial at 4℃ prior to restoration.For extended storage aliquot contents and freeze at -20℃ or below.Avoid cycles of freezing and thawing.Centrifuge product if not completely clear after standing at room temperature.This product is stable for several weeks at 4℃ as an undiluted liquid.Dilute only prior to immediate use.?Expiration date is one (1) year from date of opening. |
| 背景资料 | CaM Kinase IV (also known as CAM kinase-GR and CaMK IV) is a calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade.This kinase may be involved in the transcriptional regulation of microtubule dynamics.In vitro,CaMK IV phosphorylates CREB1,CREBBP,PRM2,MEF2A,MEF2D and STMN1/OP18.CaMK IV may also be involved in spermatogenesis and may play a role in the consolidation/retention of hippocampus-dependent long-term memory.CaMK IV must be phosphorylated to be maximally active and is phosphorylated by CAMKK1 or CAMKK2.In addition autophosphorylation of the N-terminus is required for full activation.Autophosphorylation of Ser-336 allows the kinase to switch to a Ca(2+)/calmodulin-independent state.Most likely the kinase is inactivated by the serine/threonine protein phosphatase 2A.CaMK IV is a monomer that is located within the cytoplasm and nucleus and substantial localization occurs in certain neuronal nuclei.In spermatids CaMK IV is associated with chromatin and the nuclear matrix.CaMK IV is also specifically expressed in epithelial ovarian cancer tissue. |
| Uniprot ID | Q16566 |
| 基因名全称 | Calcium/calmodulin-dependent protein kinase type IV |
| 推荐稀释比 | ELISA:1:5,000 - 1:25,000 IHC:1:500 WB:1:500 - 1:2,000 |
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